ALPHA GPC

    Intro

    Alpha-GPC (Alpha-glycerophosphocholine) is a choline-containing supplement that is also found in a variety of food sources. It is also present in your body in small amounts. Alpha-GPC is the most bio-available source of choline as it easily crosses the blood-brain barrier as compared to other sources of choline available in the market.

      Mechanism

      How does Alpha-GPC enhance brain function?

      • Alpha-GPC is a precursor to an essential neurotransmitter called acetylcholine. Acetylcholine’s function in the brain is critical for forming new memories, logical thinking, focus, cognition, and neuroplasticity. Acetylcholine deficiency can result in mental illnesses like ADD, ADHD and Alzheimer’s.
      • Alpha GPC impacts the development of the cerebral cortex which is the information processing center of your brain. It controls intelligence, motor function, organization, personality, planning and touch.

        Research

        Studies supporting the multiple nootropic benefits of Alpha-GPC

        Increase in growth hormone levels: In one study, researchers showed that Alpha GPC contributed to increased levels of human growth hormone.

        Enhanced dopamine levels: Another trial demonstrated that Alpha-GPC supplementation can boost dopamine levels in the brain. This can alleviate symptoms of depression and mood disorders.

        Improvements in learning and memory: Alpha GPC supplementation has a demonstrated ability to improve learning, attention, and memory retention.

        Reduced cognitive decline: Multiple studies have confirmed the ability of alpha-GPC to reduce age related cognitive decline.

        Enhanced power output: A pilot study noted a 14% increase in power output as assessed by bench throws. This was associated with a greater exercise-induced growth hormone increase.

        NEXTGEN coffee infused with Alpha-GPC is the most effective way to boost your cognition and protect your brain from cognitive decline in the long term.

         

        References

        1. Ziegenfuss T., Landis J. Hofheins J. “Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise” Journal of the International Society of Sports Nutrition20085(Suppl 1):P15
        2. Canal N., Franceschi M., Alberoni M., Castiglioni C., De Moliner P., Longoni A. “Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine.” International Journal of Clinical Pharmacology, Therapy, Toxicology.1991 Mar;29(3):103-7.
        3. Kidd P.M. “Neurodegeneration from mitochondrial insufficiency: nutrients, stem cells, growth factors, and prospects for brain rebuilding using integrative management.” Alternative Medicine Review2005 Dec;10(4):268-93.
        4. Drago F., Mauceri F., Nardo L., Valerio C., Lauria N., Rampello L., Guidi G. “Behavioral effects of L-alpha-glycerylphosphorylcholine: influence on cognitive mechanisms in the rat.” Pharmacology, Biochemistry and Behavior1992 Feb;41(2):445-8.
        5. Ceda G.P., Ceresini G., Denti L., Magnani D., Marchini L, Valenti G., Hoffman A.R. “Effects of cytidine 5′-diphosphocholine administration on basal and growth hormone-releasing hormone-induced growth hormone secretion in elderly subjects.” Acta Endocrinologica (Copenhagen).1991;124(5):516-20.
        6. Trabucchi M., Govoni S., Battaini F.  “Changes in the interaction between CNS cholinergic and dopaminergic neurons induced by L-alpha-glycerylphosphorylcholine, a cholinomimetic drug.” Farmaco Sci.1986 Apr;41(4):325-34.
        7. Traini E., Bramanti V., Amenta F. “Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipid with a still interesting profile as cognition enhancing agent.” Current Alzheimer’s Research2013 Dec;10(10):1070-9.
        8. Ziegenfuss, T., Landis, J. & Hofheins, J. Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise. J Int Soc Sports Nutr5, P15 (2008). https://doi.org/10.1186/1550-2783-5-S1-P15